Fungal transformation of androsta-1,4-diene-3,17-dione by Aspergillus brasiliensis
نویسندگان
چکیده
منابع مشابه
Microbial transformation of anti-cancer steroid exemestane and cytotoxicity of its metabolites against cancer cell lines
BACKGROUND Microbial transformation of steroids has been extensively used for the synthesis of steroidal drugs, that often yield novel analogues, not easy to obtain by chemical synthesis. We report here fungal transformation of a synthetic steroidal drug, exemestane, used for the treatment of breast cancer and function through inhibition of aromatase enzyme. RESULTS Microbial transformation o...
متن کاملBiotransformation of Progesterone by Whole Cells of Filamentous Fungi Aspergillus brasiliensis
Microbial steroid biotransformation have found wide-reaching application for the production of more precious and functionalized compounds due to their high regio-and stereoselectivity. In this study, the possibility of using filamentous fungi Aspergillus brasiliensis cells in the biotransformation of progesterone (I), a C-21 steroid hormone was studied for the first time.The fungal strain was i...
متن کاملBiotransformation of Progesterone by Whole Cells of Filamentous Fungi Aspergillus brasiliensis
Microbial steroid biotransformation have found wide-reaching application for the production of more precious and functionalized compounds due to their high regio-and stereoselectivity. In this study, the possibility of using filamentous fungi Aspergillus brasiliensis cells in the biotransformation of progesterone (I), a C-21 steroid hormone was studied for the first time.The fungal strain was i...
متن کاملTricyclo[6.2.1.02,7]undeca-4,9-diene-3,6-dione
The title compound, C(11)H(10)O(2), crystallizes with two independent mol-ecules in the asymmetric unit. In one mol-ecule, the dihedral angle between the mean planes of the C-C=C-C group of the diene unit and essentially planar cyclo-hexene ring is 51.07 (9)°, while in the other mol-ecule it is 54.49 (12)°. In the crystal structure, weak inter-molecular C-H⋯O inter-actions link the mol-ecules i...
متن کامل21-Hydroxypregna-1,4-diene-3,20-dione
The title compound, C(21)H(28)O(3), is a fungal transformed metabolite of decoxycorticosterone acetate, consisting of four fused rings A, B, C and D. Ring A is nearly planar, with a maximum deviation of 0.010 (3) Å from the least-squares plane, while the trans-fused rings B and C adopt chair conformations. The five-membered ring D is in an envelope conformation. The orientation of the side chai...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: DARU Journal of Pharmaceutical Sciences
سال: 2014
ISSN: 2008-2231
DOI: 10.1186/s40199-014-0071-8